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Eurolyme: sindrome del cervello che perde


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#1 joseph1951

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Inviato 22 febbraio 2008 - 19:11:20

Tratto dalla selzione delle newslteer di eurolyme:

La sindrome dell cervello permeabile, Borrelia puo' essere una delle infezioni o co-infezioni presenti in pazienti ME/CFS
Ecco il riassunto in inglese:
----------------------------------------------------------------------------------------------

Lyme disease: a leaky brain
Posted by: "Gill Reese" gilly848@eurolyme.co.uk gilly848
Fri Feb 22, 2008 1:04 am (PST)
http://www.wddty.com...eaky-brain.html

WDDTY

Lyme disease: a leaky brain

Lyme disease is still barely recognized by orthodox medicine, but new,
explosive evidence links this worldwide epidemic with certain types of
mental illness, including autism.

The first cases of Lyme disease (LD) occurred in the US, but it’s now
acknowledged to be a worldwide problem
.
Britain had its first official death due to LD in December 2005: “liver disease due to Lyme sepsis”,
according to the autopsy. In May of this year, a 38-year-old British
professor committed suicide after developing dementia brought about by
LD. It’s particularly prevalent at this time of the year—late spring and
early summer.


The number of diagnosed cases of Lyme disease are now rising—and not
just because doctors are finally beginning to recognize it, but also
possibly as a result of global warming. And, as with many new-disease
discoveries, a whole raft of previously mysterious conditions are now
being laid at the door of LD, including chronic fatigue (CFS/ME),
multiple sclerosis (MS) and even autism.
Could we be witnessing the
start of a new epidemic? “Many of the diseases that are considered
incurable by conventional medicine may have some kind of Lyme
component,” says American alternative practitioner Dr Lee Cowden.

What is Lyme disease? In essence, it’s a kind of malaria, although it
emerges not from the swampy jungle, but from temperate forests
. Like
malaria, the disease is transmitted by being bitten by a blood-feeding
creature—in the case of LD, not by an insect, but a tick, an arachnid,
that lives on animals such as cattle, birds and even mice, but primarily
deer.





Where it all began

Lyme disease first appeared more than 30 years ago as a mysterious
disease outbreak in an American town called Lyme, in Connecticut. In the
spring of 1975, there was a cluster of cases of what appeared to be
juvenile arthritis. Children as young as 10 began to develop severe
joint pain. Doctors from nearby Yale University were called in
to investigate, and were puzzled by the appearance of odd rashes on the
children’s skin. Months of detective work finally led the doctors to
connect the symptoms to a disease that had first been described in
Europe almost a century before as ‘sheep-tick fever’.

After years of further detective work, researchers traced the illness to
a rogue spirochaetes bacterium in the patients’ blood known as Borrelia
burgdorferi—hence, the alternative name of ‘Lyme borreliosis’. But where
had it come from? Already alerted to the fact that it might be due to a
tick bite, the scientists began a hunt among the local animal
population.
The Borrelia microorganism was finally tracked down to a
tick of the genus Ixodes that lives on deer. This tiny arachnid—related
to mites, spiders and scorpions, having eight legs—has a correspondingly
tiny mouth, so its bite is rarely felt, which may be one reason why it
was able to elude detection for so long. Ixodes is also cleverly able to
inject its prey with a local anaesthetic, further disguising its attack.
In fact, most victims of Lyme disease have no idea they were ever on the
tick’s hit list.

In fact, it’s likely that Ixodes has to remain undetected because it’s
believed to be an inefficient feeder. It needs to be plugged in to its
prey for hours to obtain sufficient nourishment. One indication of this
is the probability that B. burgdorferi is not transmitted until the tick
has been attached for at least 12 hours.

Initially, medicine treated the disease just like any other bacterial
infection—with antibiotics. These appeared to work, and doctors patted
themselves on the back for having put paid so easily to this novel
disease. But the story hasn’t turned out to be that simple.

Although this medical field is still relatively small, there is already
a schism appearing among LD clinicians; indeed, some would call it a
war. One army of experts believe that Lyme disease can be easily cured
by a short course of antibiotics, whereas the opposing side says no, LD
is a complex, potentially long-term illness (see box, page 6).
The problems begin with the diagnosis. If LD is spotted early on, then
antibiotics can prove helpful. But, in practice, LD turns out to be very
diffi-cult to diagnose (see box, page 8), and the later stages of the
disease are much harder to treat with the usual drugs.
What’s more, these antibiotics can sometimes make things even worse. Any
Borrelia bacteria that are not totally killed off by the drugs don’t
just develop resistance—which is bad enough—but also become what is
referred to as ‘cell-wall deficient’. This makes them very elusive as,
without walls, they can hide inside of healthy cells, thereby avoiding
direct attack by the drugs (Infection, 1996; 24: 218–26).


Lyme patients also find that the types of antibiotics used to treat them
may actually exacerbate their symptoms. This is thought to be the result
of changes due to the drugs in the genetic sequencing of Borrelia,
causing them to release toxins into the body.
These toxins often get into the brain and nervous system, precipitating what is called the
Jarisch–Herxheimer reaction
(named after Karl Herx-heimer, the German
dermatologist who first observed it). J–H reactions can be
life-threatening, and are seen in one in seven Lyme borreliosis patients
treated.

The leaky brain
In fact, it has also been suggested that LD in itself—whether treated by
antibiotics or not—may be neurotoxic. The idea is that Lyme disease
creates ammonia in the brain, causing a ‘leaky-brain syndrome’.
Among
the first to propose the idea was LD specialist Dr David Jernigan. As
ammonia can alter permeability of the blood–brain barrier, he says, it
would allow large molecules to reach the brain, causing ‘cerebral
allergies’. Jernigan believes that this may be a major cause of a
variety of LD symptoms (Townsend Lett Docs, 2007; April: 141–8; online
only).

Confirmation of this hypothesis has come from animal studies. Using
radioactive tracers, researchers have shown that laboratory animals,
when infected by Borrelia, lose the protection of the blood–brain
barrier after just two weeks (Schutzer SE, ed. Lyme Disease: Molecular
and Immunologic Approaches, Series 6. Current Communications in
Molecular and Cell Biology. Plainview, NY: Cold Spring Harbor Press, 1992).

How does Borrelia do this? It’s thought that the bacteria burrow their
way between the cells of the brain’s outermost membrane, causing a
localized inflammation that, in turn, releases proteins to fight against
the bacterial invasion; this then results in holes in the cerebral
membrane. It’s much the same mechanism as seen in the leaky-gut syndrome
but, in this case, it’s potentially more serious as it involves the brain.

In addition, there is now laboratory evidence that Borrelia can “attach
to or invade human cortical neuronal cells”, say researchers at the
National Center for Infectious Diseases in Colorado, part of the US
Centers for Disease Control and Prevention (CDC). This makes the
bacteria difficult to kill by the immune system (Microbes Infect, 2006;
8: 2832–40). It also helps to explain why Lyme disease can be both
relapsing and resistant to treatment.

Incidentally, the spirochaetes bacterium that causes syphilis has a
similar mode of action and can also lodge in the brain, potentially
remain-ing active for years.

Brain abnormalities

The leaky-brain theory also accounts for some of the highly specific
neurological abnormalities found in Lyme patients—including Bell’s
palsy, lymphocytic meningitis, meningo-encephalitis and cranial
neuritis—not to mention the less specific CFS/ME and ‘brain fog’.

“The neurological and psychiatric manifestations of Borrelia are so
numerous that it is called the ‘new great imitator’,” says Dr Frederic
Blanc, of the University of Strasbourg, France. “Every part of the
nervous system can be involved: from central to peripheral nervous
system, and even muscles” (Med Mal Infect, 2007; Mar 8; Epub ahead of
print).


In fact, as long as 10 years ago, LD was firmly characterized as a
‘neuro-psychiatric illness’. Reviewing the whole history of the disease,
a team of psychiatrists at New York’s Columbia University found Lyme
disease to be responsible for “a broad range of psychiatric reactions”,
including paranoia, dementia, schizophrenia, bipolar disorder, panic
attacks, major depression, anorexia nervosa and obsessive–compulsive
disorder (Am J Psychiatry, 1994; 151: 1571–83). Since then, tests have
discovered reduced blood flow in the brains of chronic LD sufferers,
explaining the impaired mental functioning that afflicts so many victims
of the disease (Neuro-psychiatry Clin Neurosci, 2003; 15: 326–32).


The autism connection

The most dramatic mental condition thought to be caused by Lyme disease
is autism. A rare condition 50 years ago, autism now affects one in
every 150 American children, according to the latest figures from the CDC.

But why should Lyme disease be implicated? One of the first clues was
that the psychological symptoms of
LD are similar to those of autism.

Six years ago, the above-mentioned Columbia University psychiatrists
found that children with Lyme disease have “significantly more cognitive
and psychiatric disturbances . . . resulting in psychosocial and
academic impairments” (J Neuropsychiatry Clin Neurosci, 2001; 13: 500–7).

There are other clues, too. As already mentioned, syphilis, which is
caused by a similar spirochaetes as in LD, in the womb is known to cause
autism. Furthermore, autistic children are known to have many metabolic
dysfunctions which are shared by victims of LD, in particular,
chronically low counts of CD57 natural-killer (NK) cells.

Of course, scores of theories have been proposed for the cause of
autism, among which vaccine damage is perhaps the best known. But LD may
be involved there, too. “It is possible that the two are conjoined in
damage, and the long-term effects of Borrelia could hamper the body’s
ability to mount a significant, timely response to vaccines,” says Dr
Geoffrey Radoff, of the Alternative Medical Care Center of Arizona.

“This could explain the higher incidences of adverse reactions to
vaccinations in children with autism (Townsend Lett Docs, 2007; April:
78–81; online only).


However, some children appear to be born with autism, so how could Lyme
disease be involved there? Although the research has yet to be done in
humans, studies of farm animals have shown that Borrelia can pass
through the placental barrier into the womb and even into breast milk.
This makes it possible for an infected mother to pass on the disease to
her newborn child, in whom it could present as autism.

Do the numbers stack up? With autism now so widespread, is it likely
that so many children—or their mothers—could have been bitten by a
relatively uncommon tick?

One answer is that ticks, it appears, are not the only cuplrits.
Mosquitoes, fleas and lice may also carry Borrelia (Agric Environ Med,
2002; 9: 257–9), thus vastly increasing the risk of infection. Another
theory is that there may be a ‘Borrelia-related complex’ wherein the bacteria pass unnoticed from generation to generation, and only present when the immune system is
under stress. Autistic children are known to suffer from a plethora of
autoimmune and metabolic disorders (J Autism Dev Disord, 2000; 30:
475–9), and these could turn latent Borrelia infect-ion into a
full-blown attack—with no tick in sight.

Such theories were recently aired at a January 2007 meeting of the newly
formed Lyme-Induced Autism Foundation, held in San Diego. Texas
physician Dr William Harvey reported that he had many patients who
tested positive for Borrelia, and yet, “our part of Texas is not an
endemic region of Lyme disease”, he said. “No patient had the typical
skin rash, but most
had been ill for many years, with similarly ill family members.”

Other delegates agreed. “There may be two forms of Borrelia infection:
Lyme disease and epidemic borreliosis—disease spread directly between
humans,” said fellow LD physician Dr Radoff. “It is quite possible that
the prevalence of autoimmune disorders found in families with autism is
an infection that has existed chronically in the body for years, if not
decades.”

Dr Warren Levin, another LD practitioner, has reported that, in the 10
children with autism he has seen,
all tested positive for Lyme disease.
Predictably, medicine’s knee-jerk reaction to such findings has been to
dismiss them, but one group of researchers is taking them seriously. Yet
again, that pioneering team of psychiatrists at Columbia University, led
by Dr Brian Fallon, has already taken up the challenge and embarked on a
huge epidemiological study of Lyme disease and autism.

Fallon believes that two things will emerge from his study: that regions
with very high rates of Lyme disease will also have higher-than-normal
rates of autism; and that at least some of those autistic children will
respond to LD therapy.

“In our work with children with LD, we have encountered a few children
with autistic-like disorders,” says Dr Fallon. “When they received
intensive antibiotic therapy, the autistic syndromes dramatically
improved and, in some cases, resolved.”

Tony Edwards
Story from WDDTY:
http://www.wddty.com...eaky-brain.html

Published: 04/06/2007 14:15:00 GMT

© WDDTY MMVI
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#2 raffa

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Inviato 23 febbraio 2008 - 00:12:10

veramente interessante,sarebbe ancora + interessante fare indagini diagnostiche,esami clinici a riguardo.(nn escludo di farle)
Considerando che quella del surriscaldamento globale è ormai una prova direi inconfutabile,bisognerebbe prendere in considerazione quanto hai riportato.
Se ho tradotto bene però,le zanzara,la tigre per intenderci non è nella catena di trasmissione,lo sono invece i ragni,i topi e altri tipi di insetti,o sbaglio?
Comunque la sintomatologia calza a pennello si a con la ME che con la CFS in generale!!! Grazie.

Non importa quanto lontano sei andato su una strada sbagliata: torna indietro
(Proverbio turco)

#3 joseph1951

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Inviato 23 febbraio 2008 - 21:11:10

veramente interessante,sarebbe ancora + interessante fare indagini diagnostiche,esami clinici a riguardo.(nn escludo di farle)
Considerando che quella del surriscaldamento globale è ormai una prova direi inconfutabile,bisognerebbe prendere in considerazione quanto hai riportato.
Se ho tradotto bene però,le zanzara,la tigre per intenderci non è nella catena di trasmissione,lo sono invece i ragni,i topi e altri tipi di insetti,o sbaglio?
Comunque la sintomatologia calza a pennello si a con la ME che con la CFS in generale!!! Grazie.

Visualizza Messaggio

Cara Raffa,
Prego. Nel Regno Unito il Governo ha pubblicato un libro bianco su vari scenari relativi alla diffusione delle Borrelie e cambiamenti di clima. Negli Stati Uniti, scienziati di prestigio internazionale dichiarano pubblicamente che le complcanze da borrelia (e da altri batteri che si sono evoluti, cioe mutati) affliggono, globalmente circa un miliardo di persone. Le cose si sanno da molto tempo.

La disseminazione di disinformazione perpetrata dalle lobby-governi-industria del farmaco-psichiatria (scuola di Wesseley et Al) prima o poi verra' a crollare, vista la crescita esponenziale, incessante di queste patologie.

La Borrelia (variante di Lyme) e' stata geneticamente manipolata dall'industria militare Usa come arma biologica. Le varianti europee non sono meno pericolose.
Dopo trentuadue anni dall'esordio la variante di Lyme ha fatto il giro del globo.

Una qualsiasi variazione dell'assetto biologico locale, in fase relativamente dinamica, provocata dall'intervento umano su un sistema ecologico ristretto, diciamo, confinato ad un solo continente, per esempio l'australia, provoca sconvolgimenti erratici dell'ecosistema modificato. Bastano poche cose.

Per esempio: ho citato l'Australia. Circa cento anni or sono non c'erano conigli in Australia. Sono stati introdotti nell'ecosistema australiano dagli europei. Ora sono una vera pestilenza. Poi sempre in australia, e' stata introdotta una rana velenosa, prelevata nel mato grosso. Questa rana, non solo ha mutato, ma ha fatto sparire anche tutte le rane autoctone, ed altresi' costretto i serpenti australiani che si nutrono di rane, a mutare la loro bocca, in modo che non possano mangiare queste rane letali. Ha provocato anche la scompara di un certo tipo di flora.

Questo per avere intrdotto due animaletti in un continente immenso, e in gran parte semidesertico, come l'Australia.

Oggigiorno, circa 6,5 miliardi di essere umani, vivono ed inquinano il pianeta terra, ocuppando l'80 per cento dell'habitat ecologico del pianeta. Migliaia di specie di piante, insetti, altri esseri viventi mono e pluri-cellulari , scompaiono.
Di fronte a tale sconvolgimento la natura ha accelerato i processi evolutivi.
SErvono 4 pianeta teraa per sopportare il carcio biologico di 6,5 miliardi di esseri umani che sprecano le risoerse, non rinnovabili come gli americani.

Cio' senza contare i pasticci della medicina e dell'immisione nell'ecosistema, da parte umana, di circa 1,5 milioni di sostanze chimiche, immesse nell'ecosistema planetario, da noi, negli ultimi 50 anni

In pianura padana ora abbiamo varianti di megazanzare cinesi.

Vari batteri ,quali lo stafiliccoco aureus crescono piu' rapidamente e si rafforzano in presenza dei forti campi magnetici creati dall'uomo. Stanno diventando superbatteri..

Il virus di Ebola se ne e' stato buono in una regione dello Zaire, per milioni di anni.

Ora e' presente su tutto il pianeta ed e' un filariovurs che ha gia' subito mutazioni, e contro il quale le nostra specie non ha difese.

Quindi non stupiamoci se le malattie come la ME/CFS stanno aumentando esponenzialmente in tutto il pianeta. Con la teoria della somatizzazione, io ci andrei cauto.........

Forse la razza umana non fara' in tempo a vedere appieno gli effetti globali dell'accelerazione del riscaldamento globale,da essa cusata, che poi sara' seguito da un rapidissimo raffreddamento globale (periodo glaciale).

Da circa 40 anni gruppi di scienziati seri ammoniscono i nostri governi (vedi per esempio il Libro del Club di Roma sul dapauperamento delle risorse planetarie pubblicato, agli inizi negli anni 70 - se ricordo bene).

Ma i politici continuano a fare orecchie da mercante. I politici smetteranno di fare i sordi quando sara' troppo tardi per intervenire. Detto per inciso, non abbiamo la piu' pallida idea di come mettere a posto l'ecositema planetario.




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