M.E. (Myalgic Encephalomyelitis) BASIC INFORMATION:
Anglia ME Action. April 2008. “…there are now over 4,000 published studies that show underlying
biomedical abnormalities in patients with this illness. It’s not an illness that
people can simply imagine that they have and it’s not a psychological illness.
In my view, that debate, which has waged for 20 years, should now be over”.
[Professor Anthony Komaroff, Harvard Medical School: Speaking at the USA Government CDC
(Centers for Disease Control and Prevention) press conference on 3 November 2006. – Also see
endnote 1 below] www.cdc.gov/od/oc/media/transcripts/t061103.htm
1. What ME is and What it is Not:
What is ME? What is CFS? Information for Clinicians and Lawyers.
www.meactionuk.org.uk/What_Is_ME_What_Is_CFS.htm
And see: http://meactionuk.or...compilation.jpg
http://meactionuk.or...dex-closeup.jpg
www.who.int/classifications/icd/en/
Also see discussion on the controversial United States CDC disease labelling / classification at:
www.co-cure.org www.cfids-me.org/ www.meresearch.org.uk/index.html
Biomedical Research.
Journal of Clinical Pathology; 2007; 60:466-471. Doi: 10.1136/jcp.2006.042408.
http://jcp.bmj.com/c...stract/60/5/466
For a biomedical research findings overview up to 2005 see:
Illustrations of Clinical Observations and International Research Findings from 1955 to 2005
that demonstrate the organic aetiology of Myalgic Encephalomyelitis / Chronic Fatigue
Syndrome. Malcolm Hooper, Eileen Marshall, Margaret Williams (For Gibson Inquiry):
www.meactionuk.org.uk/Organic_evidence_for_Gibson.doc
Also see: Essential investigations for people with ME/CFS? Margaret Williams. January 2008.
http://meactionuk.or...ple_with_ME.htm
Page 3 of 14
There has been much misunderstanding and downright deceit (see section 3 below) over what ME
is and is not. See Professor Malcolm Hooper's et al document entitled:
What is ME? What is CFS? Information for Clinicians and Lawyers.
www.meactionuk.org.uk/What_Is_ME_What_Is_CFS.htm
Also see: The Late Effects of ME - Can they be distinguished from the Post-polio syndrome? By
Consultant Microbiologist and ME Specialist, Dr Elizabeth (Betty) Dowsett:
www.ott.zynet.co.uk/polio/lincolnshire/library/dowsett/lateeffectsme.html
2. ME Recovery & Early Death Rates: Patients With Chronic Fatigue Syndrome. DePaul University, Chicago, Illinois, USA Health Care for Women
International, 27:615–626, 2006. Routledge. Copyright © Taylor & Francis Group, LLC. ISSN:
0739-9332 print / 1096-4665 online: DOI: 10.1080/07399330600803766
www.ingentaconnect.com/content/routledg/uhcw/2006/00000027/00000007/art00005?crawler=true
The tragic death by ME of 32 year old Sophia Mirza was recently recorded by a UK coroner and was the result of organ failure and alleged psychiatric mistreatment/neglect. See:
The Inquest of Sophia Mirza. Invest in ME:
www.investinme.org/Article-050%20Sophia%20Wilson%2001-RIP.htm
Inquest Implications:
www.meactionuk.org.uk/Inquest_Implications.htm
3. Internationally Respected ME Guidelines & Expert Comment:
See: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition,
Diagnostic and Treatment Protocols (‘Canadian Criteria’ – Full Version).
Anil Kumar Jain, Kenny L. De Meirleir, Daniel L. Peterson, Nancy G. Klimas, A. Martin Lerner, Alison C. Bested, Pierre Flor-Henry, Pradip Joshi, A. C. Peter Powles, Jeffrey A. Sherkey, Marjorie
I. van de Sande. Journal of Chronic Fatigue Syndrome. Volume 11, Number 1, 2003. At: http://fm-cfs.ca/CFS-Protocol.pdf
See: Chronic Fatigue Syndrome: Assessment and Treatment of Patients with ME/CFS: Clinical
Guidelines for Psychiatrists. Eleanor Stein MD FRCP©.
http://fm-cfs.ca/Psy...ry-overview.pdf
See: The Nightingale Definition of Myalgic Encephalomyelitis (M.E.).
Dr Byron Hyde, Nightingale Foundation, Toronto, Canada. Available at:
http://www.nightinga...finition_en.pdf
The Complexities of Diagnosis. Byron Hyde. In: Handbook of Chronic Fatigue Syndrome.
Leonard A Jason et al. John Wiley & Sons, Inc. 2003.
www.nightingale.ca/documents/ComplexitiesofDiagnosis.pdf
Dr Melvin Ramsay: Definitive Description of ME: http://meactionuk.org.uk/ramsey.html
Dr Andrew Wallis: Research Description of ME: http://meactionuk.or...definition.html
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4. Disinformation, Controversy and Vested Interests:
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5. Concerns About UK NICE/NHS Guidelines and the Evidence Base: ………………………
6. The Gibson Parliamentary Group Findings:
7. Biomedical Evidence Summaries & Key Scientific Papers / Books: …………………………..
First; to again Quote Harvard's Professor Anthony Komaroff:
“…there are now over 4,000 published studies that show underlying biomedical
abnormalities in patients with this illness. It’s not an illness that people can simply
imagine that they have and it’s not a psychological illness. In my view, that debate,
which has waged for 20 years, should now be over”.
[Professor Anthony Komaroff, Harvard Medical School: Speaking at the USA Government CDC (Centers
for Disease Control and Prevention) press conference on 3 November 2006. – Also see endnote 1 below]
www.cdc.gov/od/oc/media/transcripts/t061103.htm
Excellent regularly updated peer-reviewed overview paper - see:
Myalgic encephalomyelitis: a review with emphasis on key findings in biomedical research.
Professor M Hooper. J Clin Pathol 2007; 60:466–471. Doi: 10.1136/jcp.2006.042408.
http://jcp.bmj.com/c...stract/60/5/466
For a biomedical research overview up to 2005 see:
Illustrations of Clinical Observations and International Research Findings from 1955 to 2005
that demonstrate the organic aetiology of Myalgic Encephalomyelitis / Chronic Fatigue
Syndrome. Malcolm Hooper, Eileen Marshall, Margaret Williams (For Gibson Inquiry):
www.meactionuk.org.uk/Organic_evidence_for_Gibson.doc
For updates on ME and related research - including downloadable pdf abstracts/comments on all
published papers see: M.E. Research UK (MERUK): A Scotland based biomedical ME research/
information organization led by Dr Vance Spence, Honorary Senior Research Fellow, University of
Dundee Medical School:
www.meresearch.org.uk/
Also, for international research & ME issues updates see Co-Cure at:
www.co-cure.org/
Seven Genomic Subtypes of Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME):
a detailed analysis of gene networks and clinical phenotypes. Jonathan Kerr et al. Journal of
Clinical Pathology. 5 Dec 2007. Doi: 10.1136/jcp.2007.053553.
http://jcp.bmj.com/c...p.2007.053553v1
Review: Chronic Fatigue Syndrome. L D Devanur & J R Kerr. Journal of Clinical Virology xxx
(2006) xxx-xxx; JCV-1120; doi:10.1016/j.jcv.2006.08.013.
www.cfids-cab.org/rc/Devanur.pdf
Abnormal impedance cardiography predicts symptom severity in chronic fatigue syndrome of
disease. Peckerman A, Lamanca JJ, Dahl KA, et al. Am J Med Sci. 2003; 326:55–60.
www.cfids-cab.org/MESA/Peckerman.pdf
CFS: The Heart of the Matter - 2006 Dr Paul Cheney Seminar DVD
www.dfwcfids.org/videos/video200609cheney_about.shtml
Overview document of Dr Cheney’s DVD presentation:
www.dfwcfids.org/medical/cheney/heart04.part1a.htm
CFS is Low Output Heart Failure Secondary to Mitochondrial Failure. Dr Sarah Myhill
www.drmyhill.co.uk/article.cfm?id=381
Oxidative Stress Levels are Raised in Chronic Fatigue Syndrome and are Associated with
Clinical Symptoms. Gwen Kennedy, Vance Spence et al. Free Radical Biology & Medicine: 39
(2005) 584-589. DOI: 10.1016/j.freeradbiomed.2005.04.020.
www.cfids-cab.org/rc/Kennedy.pdf
Nitric Oxide Synthase Partial Uncoupling as a Key Switching Mechanism for the NO/ONOOCycle.
Professor Martin Pall. Medical Hypotheses (2007) 69, 821-825. Doi:
10.1016/j.mehy.2007.01.070.
www.cfids-cab.org/rc/Pall-1.pdf
Book: Explaining “Unexplained Illnesses”. Professor Martin L Pall. ISBN: 978-0-7890-2389-6:
www.haworthpress.com/store/PDFFiles/ForReps/Pall-Unexplained.pdf
Chronic Fatigue syndrome is Associated with Chronic Enterovirus Infection of the Stomach.
John K S Chia & Andrew Y Chia. Journal of Clinical Pathology 2007, 0:1-6. DOI:
10.1136/jcp.2007.050054.
http://press.pspring...ber/cp50054.pdf
Use of Valganciclovir in Patients with Elevated Antibody Titres against Human Herpesvirus-6
(HHV-6) and Epstein-Barr Virus (EBV) who were experiencing central nervous system
dysfunction including long-standing fatigue. Jose G Montoya et al. Journal of Clinical Virology;
37 Suppl. 1 (2006) S33-S38.
www.cfids-cab.org/rc/Kogelnik.pdf
Chronic fatigue Syndrome: The Need for Subtypes. Professor Leonard A Jason et al.
Neuropsychology Review, Vol. 15, No.1, March 2005. DOI: 10.1007/s11065-005-3588-2.
http://condor.depaul.edu/~ljason/
Functional neuroimaging correlates of mental fatigue induced by cognition among chronic
fatigue syndrome patients and controls. Dane B. Cook, Patrick J. O’Connor, Gudrun Lange, Jason
Steffener. PII: S1053-8119(07)00127-9. DOI: 10.1016/j.neuroimage.2007.02.033. Reference:
YNIMG 4490. NeuroImage: 2007.
www.cfids-cab.org/rc/Cook-2.pdf
And see MERUK article: Non-invasive structural and functional neuroimaging in ME/CFS at:
www.meresearch.org.uk/research/projects/neuroimage.html
Causes of Death Among Patients With Chronic Fatigue Syndrome. Leonard A. Jason, Karina
Corradi, Sara Gress, Sarah Williams, and Susan Torres-Harding. DePaul University, Chicago,
Illinois, USA Health Care for Women International, 27:615–626, 2006. Routledge. Copyright ©
Taylor & Francis Group, LLC. ISSN: 0739-9332 print / 1096-4665 online: DOI:
10.1080/07399330600803766
www.ingentaconnect.com/content/routledg/uhcw/2006/00000027/00000007/art00005?crawler=true
The Complexities of Diagnosis. Byron Hyde. In: Handbook of Chronic Fatigue Syndrome.
Leonard A Jason et al. John Wiley & Sons, Inc. 2003.
www.nightingale.ca/documents/ComplexitiesofDiagnosis.pdf
The Clinical and Scientific Basis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome.
Byron Marshall Hyde M.D. et al. The Nightingale Research Foundation. ISBN: 0-9695662-0-4.
www.nightingale.ca/index.php?target=bookoffer
Book: Enteroviral and Toxin Mediated Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
and Other Organ Pathologies. Dr John Richardson. Haworth Press, 2001. ISBN: 0-7890-1128-X.
http://www.haworthpr...oks/default.asp
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8. Websites / Updates:
ME Action UK - The Main UK biomedical ME activists and documents arch
----[1] Do bear in mind the varying patient selection criteria involved and resultant confusion and controversy – see for example Professor Malcolm Hooper's et al document entitled:
What is ME? What is CFS? Information for Clinicians and Lawyers.
www.meactionuk.org.uk/What_Is_ME_What_Is_CFS.htm
Messaggio modificato da vivolenta, 15 giugno 2008 - 11:24:52
